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Disclosure - Summary of Significant Accounting Policies - Schedule of Concentration of Risk (Details) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Summary of Significant Accounting Policies - Schedule of Concentration of Risk (Details) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Summary of Significant Accounting Policies - Schedule of Revenues by Geographic Region (Details) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Summary of Significant Accounting Policies - Schedule of Impact of Adoption of New Accounting Standard (Details) link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Fair Value Measurements - Fair Value Hierarchy for Financial Assets and Financial Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Fair Value Measurements - 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Disclosure - Research and Collaboration Arrangements - Summary of Collaboration and License Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Research and Collaboration Arrangements - Summary of Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Research and Collaboration Arrangements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100590 - Disclosure - Research and Collaboration Arrangements - Additional Information (Details 1) link:presentationLink link:calculationLink link:definitionLink 100600 - Disclosure - Research and Collaboration Arrangements - CRF Agreement - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100610 - Disclosure - Research and Collaboration Arrangements - Roche Agreement - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100620 - Disclosure - Research and Collaboration Arrangements - Roche Agreement - Additional Information (Details 1) link:presentationLink link:calculationLink link:definitionLink 100630 - Disclosure - Research and Collaboration Arrangements - CFF - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100640 - Disclosure - Research and Collaboration Arrangements - CFF - Additional Information (Details 1) link:presentationLink link:calculationLink link:definitionLink 100650 - Disclosure - License Arrangements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100660 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100670 - Disclosure - Commitments and Contingencies - summary of Components of Lease Expense (Details) link:presentationLink link:calculationLink link:definitionLink 100680 - Disclosure - Commitments and Contingencies - Summary of Supplemental Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 100690 - Disclosure - Commitments and Contingencies - Summary of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 100700 - Disclosure - Income Taxes - Schedule of Effective Tax Rate of Income Tax Expense (Benefit) Differs from Federal Statutory Rate (Details) link:presentationLink link:calculationLink link:definitionLink 100710 - Disclosure - Income Taxes - Schedule of Tax Effects of Temporary Differences to Significant Components of Deferred Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 100720 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100730 - Disclosure - Income Taxes - Reconciliation of Beginning and Ending Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 100740 - 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Disclosure - Common Stock Warrants - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100810 - Disclosure - Net Loss Per Share, Basic and Diluted - Computation of Basic and Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 100820 - Disclosure - Net Loss Per Share, Basic and Diluted - Outstanding Potentially Dilutive Securities Excluded From Computation of Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 100830 - Disclosure - Derivative Liability - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100840 - Disclosure - Related Party Transactions - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100850 - Disclosure - 401(K) Plan - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 100860 - Disclosure - Subsequent Events - 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